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Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms

The influenza A virus nucleoprotein (NP) is an essential multifunctional protein that encapsidates the viral genome and functions as an adapter between the virus and the host cell machinery. NPs from all strains of influenza A viruses contain two nuclear localization signals (NLSs): a well-studied m...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Wu, Wei, Sankhala, Rajeshwer S., Florio, Tyler J., Zhou, Lixin, Nguyen, Nhan L. T., Lokareddy, Ravi K., Cingolani, Gino, Panté, Nelly
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595889/
https://ncbi.nlm.nih.gov/pubmed/28900157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11018-1
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