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The Importin β Binding Domain Modulates the Avidity of Importin β for the Nuclear Pore Complex

Importin β mediates active passage of cellular substrates through the nuclear pore complex (NPC). Adaptors such as importin α and snurportin associate with importin β via an importin β binding (IBB) domain. The intrinsic structural flexibility of importin β allows its concerted interactions with IBB...

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Bibliografiske detaljer
Main Authors: Lott, Kaylen, Bhardwaj, Anshul, Mitrousis, Gregory, Pante, Nelly, Cingolani, Gino
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859540/
https://ncbi.nlm.nih.gov/pubmed/20197273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.095760
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