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CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination
In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA. CSR is initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues at t...
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| Pubblicato in: | Front Immunol |
|---|---|
| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5591319/ https://ncbi.nlm.nih.gov/pubmed/28928744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01076 |
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