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Duplication of a germline promoter downstream of the IgH 3′ regulatory region impairs class switch recombination
During an adaptive immune response, B cells can change their surface immunoglobulins from IgM to IgG, IgE or IgA through a process called class switch recombination (CSR). Switching is preceded by inducible non-coding germline transcription (GLT) of the selected constant gene(s), which is largely co...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6003904/ https://ncbi.nlm.nih.gov/pubmed/29907762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27448-4 |
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