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Two modes of cis-activation of switch transcription by the IgH superenhancer
B cell isotype switching plays an important role in modulating adaptive immune responses. It occurs in response to specific signals that often induce different isotype (I) promoters driving transcription of switch regions, located upstream of the Ig heavy chain (IgH) constant genes. The transcribed...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6642387/ https://ncbi.nlm.nih.gov/pubmed/31266889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902250116 |
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