Inducible CTCF insulator delays the IgH 3′ regulatory region-mediated activation of germline promoters and alters class switching

Class switch recombination (CSR) plays an important role in adaptive immune response by enabling mature B cells to switch from IgM expression to the expression of downstream isotypes. CSR is preceded by inducible germline (GL) transcription of the constant genes and is controlled by the 3′ regulator...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Braikia, Fatima-Zohra, Oudinet, Chloé, Haddad, Dania, Oruc, Zeliha, Orlando, Domenico, Dauba, Audrey, Le Bert, Marc, Khamlichi, Ahmed Amine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468671/
https://ncbi.nlm.nih.gov/pubmed/28533409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701631114
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