Inducible CTCF insulator delays the IgH 3′ regulatory region-mediated activation of germline promoters and alters class switching

Class switch recombination (CSR) plays an important role in adaptive immune response by enabling mature B cells to switch from IgM expression to the expression of downstream isotypes. CSR is preceded by inducible germline (GL) transcription of the constant genes and is controlled by the 3′ regulator...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Braikia, Fatima-Zohra, Oudinet, Chloé, Haddad, Dania, Oruc, Zeliha, Orlando, Domenico, Dauba, Audrey, Le Bert, Marc, Khamlichi, Ahmed Amine
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468671/
https://ncbi.nlm.nih.gov/pubmed/28533409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701631114
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