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Inducible CTCF insulator delays the IgH 3′ regulatory region-mediated activation of germline promoters and alters class switching
Class switch recombination (CSR) plays an important role in adaptive immune response by enabling mature B cells to switch from IgM expression to the expression of downstream isotypes. CSR is preceded by inducible germline (GL) transcription of the constant genes and is controlled by the 3′ regulator...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5468671/ https://ncbi.nlm.nih.gov/pubmed/28533409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701631114 |
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