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Amyloid beta: structure, biology and structure-based therapeutic development
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer's disease, which is the most common...
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| Publicado no: | Acta Pharmacol Sin |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5589967/ https://ncbi.nlm.nih.gov/pubmed/28713158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.28 |
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