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Amyloid beta: structure, biology and structure-based therapeutic development
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer's disease, which is the most common...
Shranjeno v:
| izdano v: | Acta Pharmacol Sin |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5589967/ https://ncbi.nlm.nih.gov/pubmed/28713158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.28 |
| Oznake: |
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