CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner

JAK2 activation is the driver mechanism in BCR-ABL-negative myeloproliferative neoplasms (MPN). These diseases are characterized by an abnormal retention of hematopoietic stem cells within the bone marrow microenvironment and their increased trafficking to extramedullary sites. The CXCL12/CXCR4 axis...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Abdelouahab, Hadjer, Zhang, Yanyan, Wittner, Monika, Oishi, Shinya, Fujii, Nobutaka, Besancenot, Rodolphe, Plo, Isabelle, Ribrag, Vincent, Solary, Eric, Vainchenker, William, Barosi, Giovanni, Louache, Fawzia
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589564/
https://ncbi.nlm.nih.gov/pubmed/28903325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10789
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