CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

Hematopoietic stem cells (HSCs) undergo self-renewal to maintain hematopoietic homeostasis for lifetime, which is regulated by the bone marrow (BM) microenvironment. The chemokine receptor CXCR4 and its ligand CXCL12 are critical factors supporting quiescence and BM retention of HSCs. Here, we repor...

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Publicado no:Sci Rep
Main Authors: Zhang, Yanyan, Dépond, Mallorie, He, Liang, Foudi, Adlen, Kwarteng, Edward Owusu, Lauret, Evelyne, Plo, Isabelle, Desterke, Christophe, Dessen, Philippe, Fujii, Nobutaka, Opolon, Paule, Herault, Olivier, Solary, Eric, Vainchenker, William, Joulin, Virginie, Louache, Fawzia, Wittner, Monika
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122894/
https://ncbi.nlm.nih.gov/pubmed/27886253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37827
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