CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model

The chemokine receptor CXCR4 favors the interaction of acute myeloid leukemia (AML) cells with their niche but the extent to which it participates in pathogenesis is unclear. Here, we show that CXCR4 expression at the surface of leukemic cells allowed distinguishing CXCR4(high) from CXCR4(neg/low) A...

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Detalhes bibliográficos
Main Authors: Zhang, Y, Patel, S, Abdelouahab, H, Wittner, M, Willekens, C, Shen, S, Betems, A, Joulin, V, Opolon, P, Bawa, O, Pasquier, F, Ito, M, Fujii, N, Gonin, P, Solary, E, Vainchenker, W, Coppo, P, De Botton, S, Louache, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481125/
https://ncbi.nlm.nih.gov/pubmed/23034331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.137
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