p19(INK4d) Controls Hematopoietic Stem Cells in a Cell-Autonomous Manner during Genotoxic Stress and through the Microenvironment during Aging

Hematopoietic stem cells (HSCs) are characterized by the capacity for self-renewal and the ability to reconstitute the entire hematopoietic compartment. Thrombopoietin maintains adult HSCs in a quiescent state through the induction of cell cycle inhibitors p57(Kip2) and p19(INK4d). Using the p19(INK...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Hilpert, Morgane, Legrand, Céline, Bluteau, Dominique, Balayn, Natalie, Betems, Aline, Bluteau, Olivier, Villeval, Jean-Luc, Louache, Fawzia, Gonin, Patrick, Debili, Najet, Plo, Isabelle, Vainchenker, William, Gilles, Laure, Raslova, Hana
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264042/
https://ncbi.nlm.nih.gov/pubmed/25458892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.10.005
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