Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

To explore how RUNX1 mutations predispose to leukemia, we generated induced pluripotent stem cells (iPSCs) from 2 pedigrees with germline RUNX1 mutations. The first, carrying a missense R174Q mutation, which acts as a dominant-negative mutant, is associated with thrombocytopenia and leukemia, and th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Antony-Debré, Iléana, Manchev, Vladimir T., Balayn, Nathalie, Bluteau, Dominique, Tomowiak, Cécile, Legrand, Céline, Langlois, Thierry, Bawa, Olivia, Tosca, Lucie, Tachdjian, Gérard, Leheup, Bruno, Debili, Najet, Plo, Isabelle, Mills, Jason A., French, Deborah L., Weiss, Mitchell J., Solary, Eric, Favier, Remi, Vainchenker, William, Raslova, Hana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347283/
https://ncbi.nlm.nih.gov/pubmed/25490895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-585513
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados