Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

To explore how RUNX1 mutations predispose to leukemia, we generated induced pluripotent stem cells (iPSCs) from 2 pedigrees with germline RUNX1 mutations. The first, carrying a missense R174Q mutation, which acts as a dominant-negative mutant, is associated with thrombocytopenia and leukemia, and th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Antony-Debré, Iléana, Manchev, Vladimir T., Balayn, Nathalie, Bluteau, Dominique, Tomowiak, Cécile, Legrand, Céline, Langlois, Thierry, Bawa, Olivia, Tosca, Lucie, Tachdjian, Gérard, Leheup, Bruno, Debili, Najet, Plo, Isabelle, Mills, Jason A., French, Deborah L., Weiss, Mitchell J., Solary, Eric, Favier, Remi, Vainchenker, William, Raslova, Hana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2015
Pynciau:
Hematopoiesis and Stem Cells
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347283/
https://ncbi.nlm.nih.gov/pubmed/25490895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-585513
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