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Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

Megakaryocytes are naturally polyploid cells that increase their ploidy by endomitosis. However, very little is known regarding the mechanism by which they escape the tetraploid checkpoint to become polyploid. Recently, it has been shown that the tetraploid checkpoint was regulated by the Hippo-p53...

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Опубликовано в: :Haematologica
Главные авторы: Roy, Anita, Lordier, Larissa, Pioche-Durieu, Catherine, Souquere, Sylvie, Roy, Lydia, Rameau, Philippe, Lapierre, Valérie, Le Cam, Eric, Plo, Isabelle, Debili, Najet, Raslova, Hana, Vainchenker, William
Формат: Artigo
Язык:Inglês
Опубликовано: Ferrata Storti Foundation 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479626/
https://ncbi.nlm.nih.gov/pubmed/27515249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.149914
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