Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

Megakaryocytes are naturally polyploid cells that increase their ploidy by endomitosis. However, very little is known regarding the mechanism by which they escape the tetraploid checkpoint to become polyploid. Recently, it has been shown that the tetraploid checkpoint was regulated by the Hippo-p53...

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Veröffentlicht in:Haematologica
Hauptverfasser: Roy, Anita, Lordier, Larissa, Pioche-Durieu, Catherine, Souquere, Sylvie, Roy, Lydia, Rameau, Philippe, Lapierre, Valérie, Le Cam, Eric, Plo, Isabelle, Debili, Najet, Raslova, Hana, Vainchenker, William
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479626/
https://ncbi.nlm.nih.gov/pubmed/27515249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.149914
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