Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

Megakaryocytes are naturally polyploid cells that increase their ploidy by endomitosis. However, very little is known regarding the mechanism by which they escape the tetraploid checkpoint to become polyploid. Recently, it has been shown that the tetraploid checkpoint was regulated by the Hippo-p53...

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發表在:Haematologica
Main Authors: Roy, Anita, Lordier, Larissa, Pioche-Durieu, Catherine, Souquere, Sylvie, Roy, Lydia, Rameau, Philippe, Lapierre, Valérie, Le Cam, Eric, Plo, Isabelle, Debili, Najet, Raslova, Hana, Vainchenker, William
格式: Artigo
語言:Inglês
出版: Ferrata Storti Foundation 2016
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479626/
https://ncbi.nlm.nih.gov/pubmed/27515249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.149914
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