Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect

Thrombocytopenia is a major side effect of a new class of anticancer agents that target histone deacetylase (HDAC). Their mechanism is poorly understood. Here, we show that HDAC6 inhibition and genetic knockdown lead to a strong decrease in human proplatelet formation (PPF). Unexpectedly, HDAC6 inhi...

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Vydáno v:Nat Commun
Hlavní autoři: Messaoudi, Kahia, Ali, Ashfaq, Ishaq, Rameez, Palazzo, Alberta, Sliwa, Dominika, Bluteau, Olivier, Souquère, Sylvie, Muller, Delphine, Diop, Khadija M., Rameau, Philippe, Lapierre, Valérie, Marolleau, Jean-Pierre, Matthias, Patrick, Godin, Isabelle, Pierron, Gérard, Thomas, Steven G., Watson, Stephen P., Droin, Nathalie, Vainchenker, William, Plo, Isabelle, Raslova, Hana, Debili, Najet
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702605/
https://ncbi.nlm.nih.gov/pubmed/29176689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01690-2
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