P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis

TP53 also known as p53 is a tumor suppressor gene mutated in a variety of cancers. P53 is involved in cell cycle, apoptosis and DNA repair mechanisms and is thus tightly controlled by many regulators. Recently, strategies to treat cancer have focused on the development of MDM2 antagonists to induce...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Mahfoudhi, Emna, Lordier, Larissa, Marty, Caroline, Pan, Jiajia, Roy, Anita, Roy, Lydia, Rameau, Philippe, Abbes, Salem, Debili, Najet, Raslova, Hana, Chang, Yunhua, Debussche, Laurent, Vainchenker, William, Plo, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077990/
https://ncbi.nlm.nih.gov/pubmed/26959882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7881
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