P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis

TP53 also known as p53 is a tumor suppressor gene mutated in a variety of cancers. P53 is involved in cell cycle, apoptosis and DNA repair mechanisms and is thus tightly controlled by many regulators. Recently, strategies to treat cancer have focused on the development of MDM2 antagonists to induce...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Mahfoudhi, Emna, Lordier, Larissa, Marty, Caroline, Pan, Jiajia, Roy, Anita, Roy, Lydia, Rameau, Philippe, Abbes, Salem, Debili, Najet, Raslova, Hana, Chang, Yunhua, Debussche, Laurent, Vainchenker, William, Plo, Isabelle
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077990/
https://ncbi.nlm.nih.gov/pubmed/26959882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7881
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