RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

RNase H1-dependent antisense oligonucleotides (ASOs) are active in reducing levels of both cytoplasmic mRNAs and nuclear retained RNAs. Although ASO activity in the nucleus has been well demonstrated, the cytoplasmic activity of ASOs is less clear. Using kinetic and subcellular fractionation studies...

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Publicado en:Mol Ther
Autores principales: Liang, Xue-Hai, Sun, Hong, Nichols, Joshua G., Crooke, Stanley T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589097/
https://ncbi.nlm.nih.gov/pubmed/28663102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.06.002
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