Improving Gene Therapy Efficiency through the Enrichment of Human Hematopoietic Stem Cells

Lentiviral vector (LV)-based hematopoietic stem cell (HSC) gene therapy is becoming a promising clinical strategy for the treatment of genetic blood diseases. However, the current approach of modifying 1 × 10(8) to 1 × 10(9) CD34(+) cells per patient requires large amounts of LV, which is expensive...

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Dettagli Bibliografici
Pubblicato in:Mol Ther
Autori principali: Masiuk, Katelyn E., Brown, Devin, Laborada, Jennifer, Hollis, Roger P., Urbinati, Fabrizia, Kohn, Donald B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589063/
https://ncbi.nlm.nih.gov/pubmed/28663101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.023
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