Enrichment of Human Hematopoietic Stem/Progenitor Cells Facilitates Transduction for Stem Cell Gene Therapy

Autologous hematopoietic stem cell (HSC) gene therapy for sickle cell disease has the potential to treat this illness without the major immunological complications associated with allogeneic transplantation. However, transduction efficiency by β-globin lentiviral vectors using CD34-enriched cell pop...

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Bibliographic Details
Published in:Stem Cells
Main Authors: Baldwin, Kismet, Urbinati, Fabrizia, Romero, Zulema, Campo–Fernandez, Beatriz, Kaufman, Michael L., Cooper, Aaron R., Masiuk, Katelyn, Hollis, Roger P., Kohn, Donald B.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074681/
https://ncbi.nlm.nih.gov/pubmed/25588820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1957
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