Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair

CRISPR/Cas9-mediated gene editing of human hematopoietic stem cells (hHSCs) is a promising strategy for the treatment of genetic blood diseases through site-specific correction of identified causal mutations. However, clinical translation is hindered by low ratio of precise gene modification using t...

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Publicat a:Stem Cells
Autors principals: Lomova, Anastasia, Clark, Danielle N., Campo-Fernandez, Beatriz, Flores-Bjurström, Carmen, Kaufman, Michael L., Fitz-Gibbon, Sorel, Wang, Xiaoyan, Miyahira, Eric Y., Brown, Devin, DeWitt, Mark A., Corn, Jacob E., Hollis, Roger P., Romero, Zulema, Kohn, Donald B.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368869/
https://ncbi.nlm.nih.gov/pubmed/30372555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2935
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