Structural insights into the interaction of the conserved mammalian proteins GAPR-1 and Beclin 1, a key autophagy protein

Mammalian Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) is a negative autophagy regulator that binds Beclin 1, a key component of the autophagosome nucleation complex. Beclin 1 residues 267–284 are required for binding GAPR-1. Here, sequence analyses, structural modeling, mutagenesi...

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Publicat a:Acta Crystallogr D Struct Biol
Autors principals: Li, Yue, Zhao, Yuting, Su, Minfei, Glover, Karen, Chakravarthy, Srinivas, Colbert, Christopher L., Levine, Beth, Sinha, Sangita C.
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2017
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586249/
https://ncbi.nlm.nih.gov/pubmed/28876241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798317011822
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