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Conformational flexibility of BECN1: Essential to its key role in autophagy and beyond

BECN1 (Beclin 1), a highly conserved eukaryotic protein, is a key regulator of autophagy, a cellular homeostasis pathway, and also participates in vacuolar protein sorting, endocytic trafficking, and apoptosis. BECN1 is important for embryonic development, the innate immune response, tumor suppressi...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Mei, Yang, Glover, Karen, Su, Minfei, Sinha, Sangita C.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029530/
https://ncbi.nlm.nih.gov/pubmed/27414988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2984
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