Conformational Flexibility Enables Function of a BECN1 Region Essential for Starvation-Mediated Autophagy

BECN1 is essential for autophagy, a critical eukaryotic cellular homeostasis pathway. Here we delineate a highly conserved BECN1 domain located between previously characterized BH3 and coiled-coil domains, and elucidate its structure and role in autophagy. The 2.0 Å Sulfur-SAD X-ray crystal structur...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Mei, Yang, Ramanathan, Arvind, Glover, Karen, Stanley, Christopher, Sanishvili, Ruslan, Chakravarthy, Srinivas, Yang, Zhongyu, Colbert, Christopher L., Sinha, Sangita
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876825/
https://ncbi.nlm.nih.gov/pubmed/26937551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01264
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