Conformational Flexibility Enables Function of a BECN1 Region Essential for Starvation-Mediated Autophagy

BECN1 is essential for autophagy, a critical eukaryotic cellular homeostasis pathway. Here we delineate a highly conserved BECN1 domain located between previously characterized BH3 and coiled-coil domains, and elucidate its structure and role in autophagy. The 2.0 Å Sulfur-SAD X-ray crystal structur...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Mei, Yang, Ramanathan, Arvind, Glover, Karen, Stanley, Christopher, Sanishvili, Ruslan, Chakravarthy, Srinivas, Yang, Zhongyu, Colbert, Christopher L., Sinha, Sangita
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876825/
https://ncbi.nlm.nih.gov/pubmed/26937551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01264
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados