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BECN2 interacts with ATG14 through a metastable coiled‐coil to mediate autophagy
ATG14 binding to BECN/Beclin homologs is essential for autophagy, a critical catabolic homeostasis pathway. Here, we show that the α‐helical, coiled‐coil domain (CCD) of BECN2, a recently identified mammalian BECN1 paralog, forms an antiparallel, curved homodimer with seven pairs of nonideal packing...
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| Izdano u: | Protein Sci |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5405433/ https://ncbi.nlm.nih.gov/pubmed/28218432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3140 |
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