SIRT1 Enzymatically Potentiates 1,25-Dihydroxyvitamin D(3) Signaling via Vitamin D Receptor Deacetylation

The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Herein, it is revealed for the first time that VDR is post-trans...

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Publicado en:J Steroid Biochem Mol Biol
Autores principales: Sabir, Marya S., Khan, Zainab, Hu, Chengcheng, Galligan, Michael A., Dussik, Christopher M., Mallick, Sanchita, Stone, Angelika Dampf, Batie, Shane F., Jacobs, Elizabeth T., Whitfield, G. Kerr, Haussler, Mark R., Heck, Michael C., Jurutka, Peter W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584940/
https://ncbi.nlm.nih.gov/pubmed/28636886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2017.06.010
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