Vitamin D Receptor Mediates a Myriad of Biological Actions Dependent on Its 1,25‐Dihydroxyvitamin D Ligand: Distinct Regulatory Themes Revealed by Induction of Klotho and Fibroblast Growth Factor‐23

The hormonal vitamin D metabolite, 1,25‐dihydroxyvitamin D [1,25(OH)(2)D], produced in kidney, acts in numerous end organs via the nuclear vitamin D receptor (VDR) to trigger molecular events that orchestrate bone mineral homeostasis. VDR is a ligand‐controlled transcription factor that obligatorily...

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Publicado en:JBMR Plus
Autores principales: Haussler, Mark R, Livingston, Sarah, Sabir, Zhela L, Haussler, Carol A, Jurutka, Peter W
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Inc. 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839824/
https://ncbi.nlm.nih.gov/pubmed/33553988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10432
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