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FGF23 gene regulation by 1,25-dihydroxyvitamin D: Opposing effects in adipocytes and osteocytes
In a closed endocrine loop, 1,25-dihydroxyvitamin D(3) (1,25D) induces the expression of fibroblast growth factor-23 (FGF23) in bone, with the phosphaturic peptide in turn acting at kidney to feedback repress CYP27B1 and induce CYP24A1 to limit the levels of 1,25D. In 3T3-L1 differentiated adipocyte...
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| Veröffentlicht in: | J Endocrinol |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4560246/ https://ncbi.nlm.nih.gov/pubmed/26148725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-15-0225 |
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