FGF23 inhibits extra-renal synthesis of 1,25-dihydroxyvitamin D in human monocytes

Vitamin D is a potent stimulator of monocyte innate immunity, with this effect being mediated via intracrine conversion of 25-hydroxyvitamin D (25OHD) to 1,25-dihydroxyvitamin D (1,25(OH)(2)D). In the kidney synthesis of 1,25(OH)(2)D is suppressed by fibroblast growth factor 23 (FGF23), via transcri...

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Main Authors: Bacchetta, Justine, Sea, Jessica L, Chun, Rene F, Lisse, Thomas S, Wesseling-Perry, Katherine, Gales, Barbara, Adams, John S., Salusky, Isidro B, Hewison, Martin
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511915/
https://ncbi.nlm.nih.gov/pubmed/22886720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1740
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