Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors

The most potent foreign antigens for natural killer T cells (NKT cells) are α-linked glycolipids, whereas NKT cell self-reactivity involves weaker recognition of structurally distinct β-linked glycolipid antigens. Here we provide the mechanism for the autoreactivity of T cell antigen receptors (TCRs...

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Udgivet i:Nat Immunol
Main Authors: Pellicci, Daniel G, Clarke, Andrew J, Patel, Onisha, Mallevaey, Thierry, Beddoe, Travis, Le Nours, Jérôme, Uldrich, Adam P, McCluskey, James, Besra, Gurdyal S, Porcelli, Steven A, Gapin, Laurent, Godfrey, Dale I, Rossjohn, Jamie
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584936/
https://ncbi.nlm.nih.gov/pubmed/21804559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2076
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