Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors

The most potent foreign antigens for natural killer T cells (NKT cells) are α-linked glycolipids, whereas NKT cell self-reactivity involves weaker recognition of structurally distinct β-linked glycolipid antigens. Here we provide the mechanism for the autoreactivity of T cell antigen receptors (TCRs...

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Publicado en:Nat Immunol
Main Authors: Pellicci, Daniel G, Clarke, Andrew J, Patel, Onisha, Mallevaey, Thierry, Beddoe, Travis, Le Nours, Jérôme, Uldrich, Adam P, McCluskey, James, Besra, Gurdyal S, Porcelli, Steven A, Gapin, Laurent, Godfrey, Dale I, Rossjohn, Jamie
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584936/
https://ncbi.nlm.nih.gov/pubmed/21804559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2076
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