Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors

The most potent foreign antigens for natural killer T cells (NKT cells) are α-linked glycolipids, whereas NKT cell self-reactivity involves weaker recognition of structurally distinct β-linked glycolipid antigens. Here we provide the mechanism for the autoreactivity of T cell antigen receptors (TCRs...

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Pubblicato in:Nat Immunol
Autori principali: Pellicci, Daniel G, Clarke, Andrew J, Patel, Onisha, Mallevaey, Thierry, Beddoe, Travis, Le Nours, Jérôme, Uldrich, Adam P, McCluskey, James, Besra, Gurdyal S, Porcelli, Steven A, Gapin, Laurent, Godfrey, Dale I, Rossjohn, Jamie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584936/
https://ncbi.nlm.nih.gov/pubmed/21804559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2076
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