BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors

Chronic cocaine use is associated with prominent morphological changes in nucleus accumbens shell (NACsh) neurons, including increases in dendritic spine density along with enhanced motivation for cocaine, but a functional relationship between these morphological and behavioral phenomena has not bee...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Anderson, Ethan M., Wissman, Anne Marie, Chemplanikal, Joyce, Buzin, Nicole, Guzman, Daniel, Larson, Erin B., Neve, Rachael L., Nestler, Eric J., Cowan, Christopher W., Self, David W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584417/
https://ncbi.nlm.nih.gov/pubmed/28808012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702441114
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