Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex

Cocaine exposure alters brain-derived neurotrophic factor (BDNF) expression in the brain. BDNF signaling through TrkB receptors differentially modulates cocaine self-administration, depending on the brain regions involved. In the present study, we determined how brain-wide inhibition of TrkB signali...

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Udgivet i:J Neurosci
Main Authors: Verheij, Michel M. M., Vendruscolo, Leandro F., Caffino, Lucia, Giannotti, Giuseppe, Cazorla, Maxime, Fumagalli, Fabio, Riva, Marco A., Homberg, Judith R., Koob, George F., Contet, Candice
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971362/
https://ncbi.nlm.nih.gov/pubmed/27488635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2711-14.2016
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