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Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety

Repeated exposure to cocaine induces lasting epigenetic changes in neurons that promote the development and persistence of addiction. One epigenetic alteration involves reductions in levels of the histone dimethyltransferase G9a in nucleus accumbens (NAc) after chronic cocaine administration. This r...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Anderson, Ethan M., Larson, Erin B., Guzman, Daniel, Wissman, Anne Marie, Neve, Rachael L., Nestler, Eric J., Self, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783964/
https://ncbi.nlm.nih.gov/pubmed/29217682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1657-17.2017
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