Overexpression of CREB in the Nucleus Accumbens Shell Increases Cocaine Reinforcement in Self-Administering Rats

Chronic exposure to addictive drugs enhances cAMP response element binding protein (CREB)-regulated gene expression in nucleus accumbens (NAc), and these effects are thought to reduce the positive hedonic effects of passive cocaine administration. Here, we used viral-mediated gene transfer to produc...

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Autors principals: Larson, Erin B., Graham, Danielle L., Arzaga, Rose R., Buzin, Nicole, Webb, Joseph, Green, Thomas A., Bass, Caroline E., Neve, Rachael L., Terwilliger, Ernest F., Nestler, Eric J., Self, David W.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229171/
https://ncbi.nlm.nih.gov/pubmed/22072694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3070-11.2011
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