EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells

DNA double-strand breaks (DSBs) can be repaired through several mechanisms, including homologous recombination (HR). While HR between identical sequences is robust in mammalian cells, HR between diverged sequences is suppressed by DNA mismatch-repair (MMR) components such as MSH2. Exonuclease I (EXO...

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Bibliographic Details
Published in:DNA Repair (Amst)
Main Authors: Chen, Chun-Chin, Avdievich, Elena, Zhang, Yongwei, Zhang, Yu, Wei, Kaichun, Lee, Kyeryoung, Edelmann, Winfried, Jasin, Maria, LaRocque, Jeannine R.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584059/
https://ncbi.nlm.nih.gov/pubmed/28711786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.07.003
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