EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells

DNA double-strand breaks (DSBs) can be repaired through several mechanisms, including homologous recombination (HR). While HR between identical sequences is robust in mammalian cells, HR between diverged sequences is suppressed by DNA mismatch-repair (MMR) components such as MSH2. Exonuclease I (EXO...

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Publicado en:DNA Repair (Amst)
Autores principales: Chen, Chun-Chin, Avdievich, Elena, Zhang, Yongwei, Zhang, Yu, Wei, Kaichun, Lee, Kyeryoung, Edelmann, Winfried, Jasin, Maria, LaRocque, Jeannine R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584059/
https://ncbi.nlm.nih.gov/pubmed/28711786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.07.003
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