Chromosome contacts in activated T cells identify autoimmune disease candidate genes

BACKGROUND: Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4(+) T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates identification of candidate disease genes. RESULTS: Within 4...

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Vydáno v:Genome Biol
Hlavní autoři: Burren, Oliver S., Rubio García, Arcadio, Javierre, Biola-Maria, Rainbow, Daniel B., Cairns, Jonathan, Cooper, Nicholas J., Lambourne, John J., Schofield, Ellen, Castro Dopico, Xaquin, Ferreira, Ricardo C., Coulson, Richard, Burden, Frances, Rowlston, Sophia P., Downes, Kate, Wingett, Steven W., Frontini, Mattia, Ouwehand, Willem H., Fraser, Peter, Spivakov, Mikhail, Todd, John A., Wicker, Linda S., Cutler, Antony J., Wallace, Chris
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584004/
https://ncbi.nlm.nih.gov/pubmed/28870212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1285-0
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