Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation. The vast majority of interactions are uncharted, constituting a major missing link in understanding genome control. Here, we use promoter capture Hi-C to identify interacting regions...

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Publicado no:Cell
Main Authors: Javierre, Biola M., Burren, Oliver S., Wilder, Steven P., Kreuzhuber, Roman, Hill, Steven M., Sewitz, Sven, Cairns, Jonathan, Wingett, Steven W., Várnai, Csilla, Thiecke, Michiel J., Burden, Frances, Farrow, Samantha, Cutler, Antony J., Rehnström, Karola, Downes, Kate, Grassi, Luigi, Kostadima, Myrto, Freire-Pritchett, Paula, Wang, Fan, Stunnenberg, Hendrik G., Todd, John A., Zerbino, Daniel R., Stegle, Oliver, Ouwehand, Willem H., Frontini, Mattia, Wallace, Chris, Spivakov, Mikhail, Fraser, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123897/
https://ncbi.nlm.nih.gov/pubmed/27863249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.09.037
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