The determination of complete human mitochondrial DNA sequences in single cells: implications for the study of somatic mitochondrial DNA point mutations

Studies of single cells have previously shown intracellular clonal expansion of mitochondrial DNA (mtDNA) mutations to levels that can cause a focal cytochrome c oxidase (COX) defect. Whilst techniques are available to study mtDNA rearrangements at the level of the single cell, recent interest has f...

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Hlavní autoři: Taylor, Robert W., Taylor, Geoffrey A., Durham, Steve E., Turnbull, Douglass M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2001
Témata:
NAR Methods Online
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC55839/
https://ncbi.nlm.nih.gov/pubmed/11470889
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