GBT1118, a potent allosteric modifier of hemoglobin O(2) affinity, increases tolerance to severe hypoxia in mice

Adaptation to hypoxia requires compensatory mechanisms that affect O(2) transport and utilization. Decreased hemoglobin (Hb) O(2) affinity is considered part of the physiological adaptive process to chronic hypoxia. However, this study explores the hypothesis that increased Hb O(2) affinity can comp...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Dufu, Kobina, Yalcin, Ozlem, Ao-ieong, Eilleen S. Y., Hutchaleelala, Athiwat, Xu, Qing, Li, Zhe, Vlahakis, Nicholas, Oksenberg, Donna, Lehrer-Graiwer, Josh, Cabrales, Pedro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582925/
https://ncbi.nlm.nih.gov/pubmed/28526710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00772.2016
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