GBT1118, a potent allosteric modifier of hemoglobin O(2) affinity, increases tolerance to severe hypoxia in mice

Adaptation to hypoxia requires compensatory mechanisms that affect O(2) transport and utilization. Decreased hemoglobin (Hb) O(2) affinity is considered part of the physiological adaptive process to chronic hypoxia. However, this study explores the hypothesis that increased Hb O(2) affinity can comp...

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Bibliografiske detaljer
Udgivet i:Am J Physiol Heart Circ Physiol
Main Authors: Dufu, Kobina, Yalcin, Ozlem, Ao-ieong, Eilleen S. Y., Hutchaleelala, Athiwat, Xu, Qing, Li, Zhe, Vlahakis, Nicholas, Oksenberg, Donna, Lehrer-Graiwer, Josh, Cabrales, Pedro
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582925/
https://ncbi.nlm.nih.gov/pubmed/28526710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00772.2016
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