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GBT1118, a potent allosteric modifier of hemoglobin O(2) affinity, increases tolerance to severe hypoxia in mice
Adaptation to hypoxia requires compensatory mechanisms that affect O(2) transport and utilization. Decreased hemoglobin (Hb) O(2) affinity is considered part of the physiological adaptive process to chronic hypoxia. However, this study explores the hypothesis that increased Hb O(2) affinity can comp...
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| Pubblicato in: | Am J Physiol Heart Circ Physiol |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5582925/ https://ncbi.nlm.nih.gov/pubmed/28526710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00772.2016 |
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