GBT1118, a potent allosteric modifier of hemoglobin O(2) affinity, increases tolerance to severe hypoxia in mice

Adaptation to hypoxia requires compensatory mechanisms that affect O(2) transport and utilization. Decreased hemoglobin (Hb) O(2) affinity is considered part of the physiological adaptive process to chronic hypoxia. However, this study explores the hypothesis that increased Hb O(2) affinity can comp...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Dufu, Kobina, Yalcin, Ozlem, Ao-ieong, Eilleen S. Y., Hutchaleelala, Athiwat, Xu, Qing, Li, Zhe, Vlahakis, Nicholas, Oksenberg, Donna, Lehrer-Graiwer, Josh, Cabrales, Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582925/
https://ncbi.nlm.nih.gov/pubmed/28526710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00772.2016
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