Increased Hemoglobin Oxygen Affinity With 5-Hydroxymethylfurfural Supports Cardiac Function During Severe Hypoxia

Acclimatization to hypoxia or high altitude involves physiological adaptation processes, to influence oxygen (O(2)) transport and utilization. Several natural products, including aromatic aldehydes and isothiocyanates stabilize the R-state of hemoglobin (Hb), increasing Hb-O(2) affinity and Hb-O(2)...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Lucas, Alfredo, Ao-ieong, Eilleen S. Y., Williams, Alexander T., Jani, Vivek P., Muller, Cynthia R., Yalcin, Ozlem, Cabrales, Pedro
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831744/
https://ncbi.nlm.nih.gov/pubmed/31736778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01350
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