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Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity

Oxygen (O(2)) delivery facilitated by hemoglobin (Hb)-based O(2) carriers (HBOCs) is a promising strategy to increase the effectiveness of chemotherapeutics for treatment of solid tumors. However, the heterogeneous vascular structures present within tumors complicates evaluating the oxygenation pote...

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Publicat a:PLoS Comput Biol
Autors principals: Belcher, Donald A., Lucas, Alfredo, Cabrales, Pedro, Palmer, Andre F.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462268/
https://ncbi.nlm.nih.gov/pubmed/32817659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008157
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