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Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction

O(2)-carrying fluids based on hemoglobin (Hb) are in various stages of clinical trials to determine their suitability as O(2)-carrying plasma expanders. Polymerized Hb solutions are characterized by their vasoactivity, low O(2) affinity, oncotic effect, prolonged shelf life, and stability. Physiolog...

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Detalhes bibliográficos
Main Authors: Cabrales, Pedro, Tsai, Amy G., Intaglietta, Marcos
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614583/
https://ncbi.nlm.nih.gov/pubmed/18835914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00751.2008
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