GBT1118, a potent allosteric modifier of hemoglobin O(2) affinity, increases tolerance to severe hypoxia in mice

Adaptation to hypoxia requires compensatory mechanisms that affect O(2) transport and utilization. Decreased hemoglobin (Hb) O(2) affinity is considered part of the physiological adaptive process to chronic hypoxia. However, this study explores the hypothesis that increased Hb O(2) affinity can comp...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Dufu, Kobina, Yalcin, Ozlem, Ao-ieong, Eilleen S. Y., Hutchaleelala, Athiwat, Xu, Qing, Li, Zhe, Vlahakis, Nicholas, Oksenberg, Donna, Lehrer-Graiwer, Josh, Cabrales, Pedro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582925/
https://ncbi.nlm.nih.gov/pubmed/28526710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00772.2016
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky