Increased hemoglobin–oxygen affinity ameliorates bleomycin‐induced hypoxemia and pulmonary fibrosis

Although exertional dyspnea and worsening hypoxia are hallmark clinical features of idiopathic pulmonary fibrosis (IPF), no drug currently available could treat them. GBT1118 is a novel orally bioavailable small molecule that binds to hemoglobin and produces a concentration‐dependent left shift of t...

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Bibliographic Details
Published in:Physiol Rep
Main Authors: Geng, Xin, Dufu, Kobina, Hutchaleelaha, Athiwat, Xu, Qing, Li, Zhe, Li, Chien‐Ming, Patel, Mira P., Vlahakis, Nicholas, Lehrer‐Graiwer, Josh, Oksenberg, Donna
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027366/
https://ncbi.nlm.nih.gov/pubmed/27624688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12965
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