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The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2–Sgs1 nuclease-helicase at DNA double strand breaks

Double strand breaks (DSBs) represent highly deleterious DNA damage and need to be accurately repaired. Homology-directed repair and non-homologous end joining (NHEJ) are the two major DSB repair pathways that are highly conserved from yeast to mammals. The choice between these pathways is largely b...

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Vydáno v:J Biol Chem
Hlavní autoři: Sorenson, Kyle S., Mahaney, Brandi L., Lees-Miller, Susan P., Cobb, Jennifer A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582849/
https://ncbi.nlm.nih.gov/pubmed/28679532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.796011
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