Nej1 Interacts with Mre11 to Regulate Tethering and Dna2 Binding at DNA Double-Strand Breaks

Non-homologous end joining (NHEJ) and homologous recombination (HR) are the two major pathways of DNA double-strand break (DSB) repair and both are highly conserved from yeast to mammals. Nej1 has a role in DNA end-tethering at a DSB, and the Mre11/Rad50/Xrs2 (MRX) complex is important for its recru...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Mojumdar, Aditya, Sorenson, Kyle, Hohl, Marcel, Toulouze, Mathias, Lees-Miller, Susan P., Dubrana, Karine, Petrini, John H.J., Cobb, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746346/
https://ncbi.nlm.nih.gov/pubmed/31390569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.018
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